Distal tubule basolateral potassium channels
نویسندگان
چکیده
منابع مشابه
Potassium secretion by distal tubule after potassium adaptation.
AND GERHARD GIEBISCH. Potassium secretion by distal tubule after potassium adaptation. Am. J. Physiol. 22 l(2) : 437-448. 197 1 .-The renal contribution to the tolerance to acute loads of potassium conferred by a chronic high-K intake was examined in rats. Changes in sodium and potassium excretion following acute K infusion were observed in animals fed normal, high-K, low-Na, or low-K diets. Co...
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Somatostatin is a powerful inhibitor of intestinal Cl- secretion. We used patch-clamp recording techniques to investigate the effects of somatostatin on low-conductance (23-pS) K+ channels in the basolateral membrane of human colonic crypts, which are an important component of the Cl- secretory process. Somatostatin (2 μM) elicited a >80% decrease in "spontaneous" K+ channel activity in cell-at...
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Apical membrane K channels in the rat connecting tubule (CNT) were studied using the patch-clamp technique. Tubules were isolated from the cortical labyrinth of the kidney and split open to provide access to the apical membrane. Cell-attached patches were formed on presumed principal and/or connecting tubule cells. The major channel type observed had a single-channel conductance of 52 pS, high ...
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متن کاملPotassium secretion and the regulation of distal nephron K channels.
K-selective channels in the luminal membranes of distal nephron segments form a key pathway for the secretion of K ions into the urine. This process is important to the control of K balance, particularly under conditions of normal or high K intake. This brief review will cover three issues: 1) the identification of apical K channels, 2) the role of these channels in the maintenance of K homeost...
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ژورنال
عنوان ژورنال: Current Opinion in Nephrology and Hypertension
سال: 2018
ISSN: 1062-4821
DOI: 10.1097/mnh.0000000000000437